منابع مشابه
Tramtrack protein-DNA interactions. A cross-linking study.
Interaction of the Tramtrack protein from Drosophila melanogaster with DNA was analyzed by a cross-linking method. Tramtrack residues cross-linkable to the partially depurinated DNA were identified by direct sequencing. The N-terminal alpha-amino group of the protein DNA-binding domain was found to be the major product of cross-linking. The location of the N terminus on the DNA was determined b...
متن کاملDiscovering Domains Mediating Protein Interactions
Background: Protein-protein interactions do not provide any direct information regarding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting domain pairs. However they do not consider the in...
متن کاملEnergetics of protein–DNA interactions
Protein-DNA interactions are vital for many processes in living cells, especially transcriptional regulation and DNA modification. To further our understanding of these important processes on the microscopic level, it is necessary that theoretical models describe the macromolecular interaction energetics accurately. While several methods have been proposed, there has not been a careful comparis...
متن کاملComputational tools for protein-DNA interactions
Interactions between DNA and proteins are central to living systems, and characterizing how and when they occur would greatly enhance our understanding of working genomes. We review the different computational problems associated with protein-DNA interactions and the various methods used to solve them. A wide range of topics is covered including physics-based models for direct and indirect reco...
متن کاملDNA–protein interactions: IHF - the master bender
The crystal structure of Escherichia coli integration host factor complexed with DNA reveals how the sequence-specificity of DNA binding can be determined almost entirely by the structural features of the DNA itself and not by direct readout of the base sequence. There are lessons to be drawn for other DNA-binding motifs.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.m001691200